Neonatal lipopolysaccharide exposure induces long-lasting learning impairment, less anxiety-like response and hippocampal injury in adult rats

Highlights ► Neonatal LPS exposure results in long-lasting learning deficits in adult rats. ► Neonatal LPS exposure causes long-lasting anxiolytic responses in adult rats. ► Neonatal LPS exposure causes persistent hippocampal injuries in adult rats. ► Neonatal LPS exposure results in chronic inflamm...

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Veröffentlicht in:	Neuroscience 2013-03, Vol.234, p.146-157
Hauptverfasser:	Wang, K.-C, Fan, L.-W, Kaizaki, A, Pang, Y, Cai, Z, Tien, L.-T
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Anti-Anxiety Agents - administration & dosage Anti-Anxiety Agents - pharmacology Anxiety - chemically induced anxiolytic behavior Atrophy - chemically induced Atrophy - pathology Biological and medical sciences chronic inflammation Female Fundamental and applied biological sciences. Psychology hippocampus Hippocampus - drug effects Hippocampus - injuries Hippocampus - metabolism Hippocampus - pathology Hypertrophy - chemically induced Hypertrophy - pathology Interleukin-1beta - metabolism Lateral Ventricles - drug effects Lateral Ventricles - pathology Learning - drug effects learning dysfunction lipopolysaccharide Lipopolysaccharides - administration & dosage Lipopolysaccharides - pharmacology Medical sciences Microglia - drug effects Microinjections Motor Activity - drug effects Nerve Degeneration - chemically induced Neurology Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► Neonatal LPS exposure results in long-lasting learning deficits in adult rats. ► Neonatal LPS exposure causes long-lasting anxiolytic responses in adult rats. ► Neonatal LPS exposure causes persistent hippocampal injuries in adult rats. ► Neonatal LPS exposure results in chronic inflammatory responses in adult rats.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.12.049