Ventilatory responses during and following exposure to a hypoxic challenge in conscious mice deficient or null in S-nitrosoglutathione reductase

Highlights ► Initial ventilatory responses to hypoxic challenge were similar in WT and GSNOR deficient mice. ► Ventilatory roll-off occurred during hypoxic challenge in WT but not in GSNOR deficient mice. ► Post-hypoxia responses were greater in female GSNOR deficient mice than in female WT mice....

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Veröffentlicht in:Respiratory physiology & neurobiology 2013-02, Vol.185 (3), p.571-581
Hauptverfasser: Palmer, Lisa A, May, Walter J, deRonde, Kimberly, Brown-Steinke, Kathleen, Bates, James N, Gaston, Benjamin, Lewis, Stephen J
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Sprache:eng
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Zusammenfassung:Highlights ► Initial ventilatory responses to hypoxic challenge were similar in WT and GSNOR deficient mice. ► Ventilatory roll-off occurred during hypoxic challenge in WT but not in GSNOR deficient mice. ► Post-hypoxia responses were greater in female GSNOR deficient mice than in female WT mice.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2012.11.009