Timing of radiotherapy in breast-conserving therapy: a large prospective cohort study of node-negative breast cancer patients without adjuvant systemic therapy

Background: To investigate the issue of timing of radiation therapy (RT) after lumpectomy in relation to recurrences and outcome. Methods: Analysis was done on 1107 breast-conserving therapies (BCT) with 1070 women, all without lymph node metastasis and without any adjuvant systemic therapy. Timing...

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Veröffentlicht in:	British journal of cancer 2013-03, Vol.108 (4), p.820-825
Hauptverfasser:	Jobsen, J J, van der Palen, J, Baum, M, Brinkhuis, M, Struikmans, H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/485 692/699/67/1347 692/700/565/545/546 Adult Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Cancer Research Cancer therapies Clinical Study Cohort analysis Cohort Studies Combined Modality Therapy Disease-Free Survival Drug Resistance Epidemiology Female Gynecology. Andrology. Obstetrics Humans Hypotheses Lumpectomy Lymphatic Metastasis Lymphatic system Mammary gland diseases Mastectomy, Segmental Medical prognosis Medical research Medical sciences Metastasis Middle Aged Molecular Medicine Oncology Prospective Studies Radiation therapy Radiotherapy, Adjuvant - methods Time Factors Tumors Womens health
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Beschreibung
Zusammenfassung:	Background: To investigate the issue of timing of radiation therapy (RT) after lumpectomy in relation to recurrences and outcome. Methods: Analysis was done on 1107 breast-conserving therapies (BCT) with 1070 women, all without lymph node metastasis and without any adjuvant systemic therapy. Timing was defined as time from lumpectomy till RT. Patients were categorised into tertiles:
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2013.36