Serum Concentrations of 1,25-Dihydroxyvitamin D2 and 1,25-Dihydroxyvitamin D3 in Response to Vitamin D2 and Vitamin D3 Supplementation
Objective: The purpose of this study was to determine 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 1,25-dihydroxyvitamin D2 [1,25(OH)2D2] levels in healthy adults consuming 1000 IU vitamin D2 or vitamin D3 per day for 11 weeks. Subjects and Design: Blood from 34 healthy male and female adults, aged 18...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2013-03, Vol.98 (3), p.973-979 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Biancuzzo, Rachael M Clarke, Nigel Reitz, Richard E Travison, Thomas G Holick, Michael F |
| description | Objective:
The purpose of this study was to determine 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 1,25-dihydroxyvitamin D2 [1,25(OH)2D2] levels in healthy adults consuming 1000 IU vitamin D2 or vitamin D3 per day for 11 weeks.
Subjects and Design:
Blood from 34 healthy male and female adults, aged 18 to 79 years, from a placebo-controlled, double-blind study who received a placebo, 1000 IU vitamin D3, or 1000 IU vitamin D2 daily for 11 weeks at end of winter was analyzed. Serum levels of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, 1,25(OH)2D2, and 1,25(OH)2D3 were determined by liquid chromatography–tandem mass spectroscopy.
Results:
Of the adults, 82% were vitamin D insufficient (serum 25-hydroxyvitamin D [25(OH)D |
| doi_str_mv | 10.1210/jc.2012-2114 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3590486</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>23386645</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4619-e28092df96c522838e0a3d9a20cae58eb7b5a7d9611bfa9629311cce3cd4b5fc3</originalsourceid><addsrcrecordid>eNp1kUtv1DAUhS0EotPCjjXKhl1TfP1I4g0SmpaHVAmJQsXOcpwbJkNiR3bSMn-gvxsPKS2VwJJtWfe759g-hLwAegIM6OutPWEUWM4AxCOyAiVkXoIqH5MVpQxyVbJvB-Qwxi2lIITkT8kB47wqCiFX5OYCwzxka-8suimYqfMuZr7N4JjJ_LTb7Jrgf-6uuskMnctOWWZc878iz9L6GeOYNDCbfHb5sO3yHryYx7HHIXn-tnxGnrSmj_j8dj8iX9-dfVl_yM8_vf-4fnueW1GAypFVVLGmVYWVjFW8Qmp4owyj1qCssC5racpGFQB1a1TBFAewFrltRC1by4_Im0V3nOsBm-XNvR5DN5iw0950-mHFdRv93V9pLhUVVZEEjhcBG3yMAdu7XqB6n4feWr3PQ-_zSPjLv_3u4D8BJODVLWCiNX0bjLNdvOdKoEryPScW7tr3E4b4o5-vMegNmn7aaJqGKMoqT86c8nTK0wSV2vjShq7xNnQOx4Ax6q2fg0sf_e9b_wICKbUb</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Serum Concentrations of 1,25-Dihydroxyvitamin D2 and 1,25-Dihydroxyvitamin D3 in Response to Vitamin D2 and Vitamin D3 Supplementation</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Biancuzzo, Rachael M ; Clarke, Nigel ; Reitz, Richard E ; Travison, Thomas G ; Holick, Michael F</creator><creatorcontrib>Biancuzzo, Rachael M ; Clarke, Nigel ; Reitz, Richard E ; Travison, Thomas G ; Holick, Michael F</creatorcontrib><description>Objective:
The purpose of this study was to determine 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 1,25-dihydroxyvitamin D2 [1,25(OH)2D2] levels in healthy adults consuming 1000 IU vitamin D2 or vitamin D3 per day for 11 weeks.
Subjects and Design:
Blood from 34 healthy male and female adults, aged 18 to 79 years, from a placebo-controlled, double-blind study who received a placebo, 1000 IU vitamin D3, or 1000 IU vitamin D2 daily for 11 weeks at end of winter was analyzed. Serum levels of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, 1,25(OH)2D2, and 1,25(OH)2D3 were determined by liquid chromatography–tandem mass spectroscopy.
Results:
Of the adults, 82% were vitamin D insufficient (serum 25-hydroxyvitamin D [25(OH)D <30 ng/mL]) at the start of the study. Administration of vitamin D2 and vitamin D3 induced similar increases in total 25(OH)D as well as in 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, respectively. Compared with placebo and adjusting for baseline levels, 1000 IU daily of vitamin D2 was associated with a mean increase of 7.4 pg/mL (95% confidence interval, 4.4–10.3) in 1,25(OH)2D2, which was accompanied by a mean decrease of 9.9 pg/mL (−15.8 to −4.0) in 1,25(OH)2D3. No such differences accompanied administration of 1000 IU daily of vitamin D3.
Conclusion:
Vitamin D2 and vitamin D3 were effective in raising and maintaining total serum concentrations of 25(OH)D. Ingestion of vitamin D2 also resulted in an increase in serum concentrations of 1,25(OH)2D2. This increase was accompanied by a comparable decrease in serum concentrations of 1,25(OH)2D3; therefore, the total 1,25-dihydroxyvitamin D [1,25(OH)2D] concentrations did not significantly change after 11 weeks compared with baseline levels. Ingestion of vitamin D3 did not alter serum concentrations of 1,25(OH)2D3 or total 1,25(OH)2D. Therefore, ingestion of 1000 IU vitamin D2 or vitamin D3 for 11 weeks was effective in raising total serum concentrations of 25(OH)D as well as sustaining serum concentrations of total 1,25(OH)2D.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2012-2114</identifier><identifier>PMID: 23386645</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Calcitriol - blood ; Cholecalciferol - administration & dosage ; Cholecalciferol - blood ; Cholecalciferol - pharmacokinetics ; Chromatography, Liquid ; Dose-Response Relationship, Drug ; Double-Blind Method ; Endocrine Care ; Endocrinopathies ; Ergocalciferols - administration & dosage ; Ergocalciferols - blood ; Ergocalciferols - pharmacokinetics ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Placebos ; Reference Values ; Regression Analysis ; Tandem Mass Spectrometry ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Vitamins - administration & dosage ; Vitamins - blood ; Vitamins - pharmacokinetics ; Young Adult</subject><ispartof>The journal of clinical endocrinology and metabolism, 2013-03, Vol.98 (3), p.973-979</ispartof><rights>Copyright © 2013 by The Endocrine Society</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 by The Endocrine Society 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4619-e28092df96c522838e0a3d9a20cae58eb7b5a7d9611bfa9629311cce3cd4b5fc3</citedby><cites>FETCH-LOGICAL-c4619-e28092df96c522838e0a3d9a20cae58eb7b5a7d9611bfa9629311cce3cd4b5fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27109535$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23386645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biancuzzo, Rachael M</creatorcontrib><creatorcontrib>Clarke, Nigel</creatorcontrib><creatorcontrib>Reitz, Richard E</creatorcontrib><creatorcontrib>Travison, Thomas G</creatorcontrib><creatorcontrib>Holick, Michael F</creatorcontrib><title>Serum Concentrations of 1,25-Dihydroxyvitamin D2 and 1,25-Dihydroxyvitamin D3 in Response to Vitamin D2 and Vitamin D3 Supplementation</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Objective:
The purpose of this study was to determine 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 1,25-dihydroxyvitamin D2 [1,25(OH)2D2] levels in healthy adults consuming 1000 IU vitamin D2 or vitamin D3 per day for 11 weeks.
Subjects and Design:
Blood from 34 healthy male and female adults, aged 18 to 79 years, from a placebo-controlled, double-blind study who received a placebo, 1000 IU vitamin D3, or 1000 IU vitamin D2 daily for 11 weeks at end of winter was analyzed. Serum levels of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, 1,25(OH)2D2, and 1,25(OH)2D3 were determined by liquid chromatography–tandem mass spectroscopy.
Results:
Of the adults, 82% were vitamin D insufficient (serum 25-hydroxyvitamin D [25(OH)D <30 ng/mL]) at the start of the study. Administration of vitamin D2 and vitamin D3 induced similar increases in total 25(OH)D as well as in 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, respectively. Compared with placebo and adjusting for baseline levels, 1000 IU daily of vitamin D2 was associated with a mean increase of 7.4 pg/mL (95% confidence interval, 4.4–10.3) in 1,25(OH)2D2, which was accompanied by a mean decrease of 9.9 pg/mL (−15.8 to −4.0) in 1,25(OH)2D3. No such differences accompanied administration of 1000 IU daily of vitamin D3.
Conclusion:
Vitamin D2 and vitamin D3 were effective in raising and maintaining total serum concentrations of 25(OH)D. Ingestion of vitamin D2 also resulted in an increase in serum concentrations of 1,25(OH)2D2. This increase was accompanied by a comparable decrease in serum concentrations of 1,25(OH)2D3; therefore, the total 1,25-dihydroxyvitamin D [1,25(OH)2D] concentrations did not significantly change after 11 weeks compared with baseline levels. Ingestion of vitamin D3 did not alter serum concentrations of 1,25(OH)2D3 or total 1,25(OH)2D. Therefore, ingestion of 1000 IU vitamin D2 or vitamin D3 for 11 weeks was effective in raising total serum concentrations of 25(OH)D as well as sustaining serum concentrations of total 1,25(OH)2D.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Calcitriol - blood</subject><subject>Cholecalciferol - administration & dosage</subject><subject>Cholecalciferol - blood</subject><subject>Cholecalciferol - pharmacokinetics</subject><subject>Chromatography, Liquid</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Endocrine Care</subject><subject>Endocrinopathies</subject><subject>Ergocalciferols - administration & dosage</subject><subject>Ergocalciferols - blood</subject><subject>Ergocalciferols - pharmacokinetics</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Placebos</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Tandem Mass Spectrometry</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><subject>Vitamins - administration & dosage</subject><subject>Vitamins - blood</subject><subject>Vitamins - pharmacokinetics</subject><subject>Young Adult</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtv1DAUhS0EotPCjjXKhl1TfP1I4g0SmpaHVAmJQsXOcpwbJkNiR3bSMn-gvxsPKS2VwJJtWfe759g-hLwAegIM6OutPWEUWM4AxCOyAiVkXoIqH5MVpQxyVbJvB-Qwxi2lIITkT8kB47wqCiFX5OYCwzxka-8suimYqfMuZr7N4JjJ_LTb7Jrgf-6uuskMnctOWWZc878iz9L6GeOYNDCbfHb5sO3yHryYx7HHIXn-tnxGnrSmj_j8dj8iX9-dfVl_yM8_vf-4fnueW1GAypFVVLGmVYWVjFW8Qmp4owyj1qCssC5racpGFQB1a1TBFAewFrltRC1by4_Im0V3nOsBm-XNvR5DN5iw0950-mHFdRv93V9pLhUVVZEEjhcBG3yMAdu7XqB6n4feWr3PQ-_zSPjLv_3u4D8BJODVLWCiNX0bjLNdvOdKoEryPScW7tr3E4b4o5-vMegNmn7aaJqGKMoqT86c8nTK0wSV2vjShq7xNnQOx4Ax6q2fg0sf_e9b_wICKbUb</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Biancuzzo, Rachael M</creator><creator>Clarke, Nigel</creator><creator>Reitz, Richard E</creator><creator>Travison, Thomas G</creator><creator>Holick, Michael F</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201303</creationdate><title>Serum Concentrations of 1,25-Dihydroxyvitamin D2 and 1,25-Dihydroxyvitamin D3 in Response to Vitamin D2 and Vitamin D3 Supplementation</title><author>Biancuzzo, Rachael M ; Clarke, Nigel ; Reitz, Richard E ; Travison, Thomas G ; Holick, Michael F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4619-e28092df96c522838e0a3d9a20cae58eb7b5a7d9611bfa9629311cce3cd4b5fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Calcitriol - blood</topic><topic>Cholecalciferol - administration & dosage</topic><topic>Cholecalciferol - blood</topic><topic>Cholecalciferol - pharmacokinetics</topic><topic>Chromatography, Liquid</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Endocrine Care</topic><topic>Endocrinopathies</topic><topic>Ergocalciferols - administration & dosage</topic><topic>Ergocalciferols - blood</topic><topic>Ergocalciferols - pharmacokinetics</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Placebos</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Tandem Mass Spectrometry</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><topic>Vitamins - administration & dosage</topic><topic>Vitamins - blood</topic><topic>Vitamins - pharmacokinetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biancuzzo, Rachael M</creatorcontrib><creatorcontrib>Clarke, Nigel</creatorcontrib><creatorcontrib>Reitz, Richard E</creatorcontrib><creatorcontrib>Travison, Thomas G</creatorcontrib><creatorcontrib>Holick, Michael F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biancuzzo, Rachael M</au><au>Clarke, Nigel</au><au>Reitz, Richard E</au><au>Travison, Thomas G</au><au>Holick, Michael F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Concentrations of 1,25-Dihydroxyvitamin D2 and 1,25-Dihydroxyvitamin D3 in Response to Vitamin D2 and Vitamin D3 Supplementation</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2013-03</date><risdate>2013</risdate><volume>98</volume><issue>3</issue><spage>973</spage><epage>979</epage><pages>973-979</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Objective:
The purpose of this study was to determine 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 1,25-dihydroxyvitamin D2 [1,25(OH)2D2] levels in healthy adults consuming 1000 IU vitamin D2 or vitamin D3 per day for 11 weeks.
Subjects and Design:
Blood from 34 healthy male and female adults, aged 18 to 79 years, from a placebo-controlled, double-blind study who received a placebo, 1000 IU vitamin D3, or 1000 IU vitamin D2 daily for 11 weeks at end of winter was analyzed. Serum levels of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, 1,25(OH)2D2, and 1,25(OH)2D3 were determined by liquid chromatography–tandem mass spectroscopy.
Results:
Of the adults, 82% were vitamin D insufficient (serum 25-hydroxyvitamin D [25(OH)D <30 ng/mL]) at the start of the study. Administration of vitamin D2 and vitamin D3 induced similar increases in total 25(OH)D as well as in 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, respectively. Compared with placebo and adjusting for baseline levels, 1000 IU daily of vitamin D2 was associated with a mean increase of 7.4 pg/mL (95% confidence interval, 4.4–10.3) in 1,25(OH)2D2, which was accompanied by a mean decrease of 9.9 pg/mL (−15.8 to −4.0) in 1,25(OH)2D3. No such differences accompanied administration of 1000 IU daily of vitamin D3.
Conclusion:
Vitamin D2 and vitamin D3 were effective in raising and maintaining total serum concentrations of 25(OH)D. Ingestion of vitamin D2 also resulted in an increase in serum concentrations of 1,25(OH)2D2. This increase was accompanied by a comparable decrease in serum concentrations of 1,25(OH)2D3; therefore, the total 1,25-dihydroxyvitamin D [1,25(OH)2D] concentrations did not significantly change after 11 weeks compared with baseline levels. Ingestion of vitamin D3 did not alter serum concentrations of 1,25(OH)2D3 or total 1,25(OH)2D. Therefore, ingestion of 1000 IU vitamin D2 or vitamin D3 for 11 weeks was effective in raising total serum concentrations of 25(OH)D as well as sustaining serum concentrations of total 1,25(OH)2D.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>23386645</pmid><doi>10.1210/jc.2012-2114</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2013-03, Vol.98 (3), p.973-979 |
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| source | MEDLINE; Journals@Ovid Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Biological and medical sciences Calcitriol - blood Cholecalciferol - administration & dosage Cholecalciferol - blood Cholecalciferol - pharmacokinetics Chromatography, Liquid Dose-Response Relationship, Drug Double-Blind Method Endocrine Care Endocrinopathies Ergocalciferols - administration & dosage Ergocalciferols - blood Ergocalciferols - pharmacokinetics Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Longitudinal Studies Male Medical sciences Middle Aged Placebos Reference Values Regression Analysis Tandem Mass Spectrometry Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Vitamins - administration & dosage Vitamins - blood Vitamins - pharmacokinetics Young Adult |
| title | Serum Concentrations of 1,25-Dihydroxyvitamin D2 and 1,25-Dihydroxyvitamin D3 in Response to Vitamin D2 and Vitamin D3 Supplementation |
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