Serum Concentrations of 1,25-Dihydroxyvitamin D2 and 1,25-Dihydroxyvitamin D3 in Response to Vitamin D2 and Vitamin D3 Supplementation

Objective: The purpose of this study was to determine 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 1,25-dihydroxyvitamin D2 [1,25(OH)2D2] levels in healthy adults consuming 1000 IU vitamin D2 or vitamin D3 per day for 11 weeks. Subjects and Design: Blood from 34 healthy male and female adults, aged 18...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2013-03, Vol.98 (3), p.973-979
Hauptverfasser:	Biancuzzo, Rachael M, Clarke, Nigel, Reitz, Richard E, Travison, Thomas G, Holick, Michael F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Calcitriol - blood Cholecalciferol - administration & dosage Cholecalciferol - blood Cholecalciferol - pharmacokinetics Chromatography, Liquid Dose-Response Relationship, Drug Double-Blind Method Endocrine Care Endocrinopathies Ergocalciferols - administration & dosage Ergocalciferols - blood Ergocalciferols - pharmacokinetics Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Longitudinal Studies Male Medical sciences Middle Aged Placebos Reference Values Regression Analysis Tandem Mass Spectrometry Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Vitamins - administration & dosage Vitamins - blood Vitamins - pharmacokinetics Young Adult
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Zusammenfassung:	Objective: The purpose of this study was to determine 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 1,25-dihydroxyvitamin D2 [1,25(OH)2D2] levels in healthy adults consuming 1000 IU vitamin D2 or vitamin D3 per day for 11 weeks. Subjects and Design: Blood from 34 healthy male and female adults, aged 18 to 79 years, from a placebo-controlled, double-blind study who received a placebo, 1000 IU vitamin D3, or 1000 IU vitamin D2 daily for 11 weeks at end of winter was analyzed. Serum levels of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, 1,25(OH)2D2, and 1,25(OH)2D3 were determined by liquid chromatography–tandem mass spectroscopy. Results: Of the adults, 82% were vitamin D insufficient (serum 25-hydroxyvitamin D [25(OH)D
ISSN:	0021-972X 1945-7197
DOI:	10.1210/jc.2012-2114