Facile and General Synthesis of Photoactivatable Xanthene Dyes
Despite the apparent simplicity of the xanthene fluorophores, the preparation of caged derivatives with free carboxy groups remains a synthetic challenge. A straightforward and flexible strategy for preparing rhodamine and fluorescein derivatives was developed using reduced, “leuco” intermediates....
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| Veröffentlicht in: | Angewandte Chemie International Edition 2011-11, Vol.50 (47), p.11206-11209 |
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| container_end_page | 11209 |
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| container_issue | 47 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Wysocki, Laura M. Grimm, Jonathan B. Tkachuk, Ariana N. Brown, Timothy A. Betzig, Eric Lavis, Luke D. |
| description | Despite the apparent simplicity of the xanthene fluorophores, the preparation of caged derivatives with free carboxy groups remains a synthetic challenge. A straightforward and flexible strategy for preparing rhodamine and fluorescein derivatives was developed using reduced, “leuco” intermediates. |
| doi_str_mv | 10.1002/anie.201104571 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2011-11, Vol.50 (47), p.11206-11209 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | 3T3 Cells Animals caged compounds Cell Nucleus - ultrastructure Communications Contrast Media - chemical synthesis Contrast Media - chemistry Contrast Media - radiation effects fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - radiation effects imaging agents Mice Microscopy, Fluorescence Molecular Structure Photochemistry rhodamine super-resolution microscopy Xanthines - chemical synthesis Xanthines - chemistry Xanthines - radiation effects |
| title | Facile and General Synthesis of Photoactivatable Xanthene Dyes |
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