Facile and General Synthesis of Photoactivatable Xanthene Dyes

Despite the apparent simplicity of the xanthene fluorophores, the preparation of caged derivatives with free carboxy groups remains a synthetic challenge. A straightforward and flexible strategy for preparing rhodamine and fluorescein derivatives was developed using reduced, “leuco” intermediates....

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Veröffentlicht in:	Angewandte Chemie International Edition 2011-11, Vol.50 (47), p.11206-11209
Hauptverfasser:	Wysocki, Laura M., Grimm, Jonathan B., Tkachuk, Ariana N., Brown, Timothy A., Betzig, Eric, Lavis, Luke D.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals caged compounds Cell Nucleus - ultrastructure Communications Contrast Media - chemical synthesis Contrast Media - chemistry Contrast Media - radiation effects fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - radiation effects imaging agents Mice Microscopy, Fluorescence Molecular Structure Photochemistry rhodamine super-resolution microscopy Xanthines - chemical synthesis Xanthines - chemistry Xanthines - radiation effects
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Beschreibung
Zusammenfassung:	Despite the apparent simplicity of the xanthene fluorophores, the preparation of caged derivatives with free carboxy groups remains a synthetic challenge. A straightforward and flexible strategy for preparing rhodamine and fluorescein derivatives was developed using reduced, “leuco” intermediates.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201104571