Post-exposure immunization against Francisella tularensis membrane proteins augments protective efficacy of gentamicin in a mouse model of pneumonic tularemia

Highlights ► These studies provide direct evidence for immunotherapy to treat tularemia. ► Post-exposure vaccination augments suboptimal antibiotic therapy of tularemia. ► Post-exposure vaccination reduces the load of F. tularensis in distal organs. ► Passive transfer of anti- F. tularensis antibodi...

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Veröffentlicht in:	Vaccine 2012-07, Vol.30 (33), p.4977-4982
Hauptverfasser:	Sutherland, Marjorie D, Goodyear, Andrew W, Troyer, Ryan M, Chandler, Jeffrey C, Dow, Steven W, Belisle, John T
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology animal models Animals Anti-Bacterial Agents - administration & dosage Antibiotic Prophylaxis - methods Antibodies antigens Bacterial Load Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology disease control Disease Models, Animal drug therapy Female Francisella tularensis Francisella tularensis - immunology gentamicin Gentamicins - administration & dosage immunization liver Liver - microbiology Membrane proteins Membrane Proteins - administration & dosage Membrane Proteins - immunology Mice Mice, Inbred BALB C microbial load Post-Exposure Prophylaxis - methods spleen Spleen - microbiology Survival Analysis Treatment Outcome tularemia Tularemia - prevention & control Vaccination - methods vaccines
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Beschreibung
Zusammenfassung:	Highlights ► These studies provide direct evidence for immunotherapy to treat tularemia. ► Post-exposure vaccination augments suboptimal antibiotic therapy of tularemia. ► Post-exposure vaccination reduces the load of F. tularensis in distal organs. ► Passive transfer of anti- F. tularensis antibodies augments treatment of tularemia.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.05.037