Observational Study of Once-Daily Insulin Detemir in People with Type 2 Diabetes Aged 75 Years or Older: A Sub-Analysis of Data from the Study of Once-Daily Levemir (SOLVE)

Objectives Older patients are particularly vulnerable to hypoglycaemia. The aim of this study was to evaluate the response to initiation of once-daily insulin detemir in patients aged ≥75 years with type 2 diabetes mellitus (T2DM) treated with one or more oral antidiabetic drugs (OADs). Methods A sub-analysis was conducted using data from SOLVE (Study of Once daily LeVEmir), a 24-week observational study involving 3,219 investigators and 2,817 project sites from ten countries. Routine clinical practice was followed; there were no study-prescribed procedures. The total cohort comprised 17,374 participants, of whom 2,398 (14 %) were aged ≥75 years. The physicians collected information from patient recall, the patients’ medical records and their self-monitored blood glucose diaries (if kept). Results Pre-insulin glycated haemoglobin (HbA 1c ) was similar between participants aged ≥75 years and those aged