Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains

Highlights ► Six adjuvants with Sabin inactivated poliovirus vaccine were evaluated in rats. ► The increase of neutralizing antibodies was 3-, 15-, 24-fold for types 1, 2 and 3. ► After boost the increase was another 7-, 20-, 27-fold. ► It is feasible to increase the potency of polio vaccine by adju...

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Veröffentlicht in:	Vaccine 2013-02, Vol.31 (9), p.1298-1304
Hauptverfasser:	Westdijk, Janny, Koedam, Patrick, Barro, Mario, Steil, Benjamin P, Collin, Nicolas, Vedvick, Thomas S, Bakker, Wilfried A.M, van der Ley, Peter, Kersten, Gideon
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvants Adjuvants, Immunologic - administration & dosage Allergy and Immunology AlOH3 Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood antigens Applied microbiology Biological and medical sciences Chromatography Confidence intervals Costs Fundamental and applied biological sciences. Psychology Human viral diseases Immune system Infectious diseases Lipids Medical sciences Microbiology MPL neutralization Neutralization Tests neutralizing antibodies Oil-in water PagL Particle size Poliomyelitis Poliovirus - immunology Poliovirus Vaccine, Inactivated - administration & dosage Poliovirus Vaccine, Inactivated - immunology Poliovirus Vaccines - administration & dosage Poliovirus Vaccines - immunology Rats Replicon particles Rodents Sabin IPV secondary immunization serotypes Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral diseases of the nervous system viruses
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Beschreibung
Zusammenfassung:	Highlights ► Six adjuvants with Sabin inactivated poliovirus vaccine were evaluated in rats. ► The increase of neutralizing antibodies was 3-, 15-, 24-fold for types 1, 2 and 3. ► After boost the increase was another 7-, 20-, 27-fold. ► It is feasible to increase the potency of polio vaccine by adjuvants.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.12.076