Stem cells and modeling of autism spectrum disorders

Human neurons, generated from reprogrammed somatic cells isolated from live patients, bring a new perspective on the understanding of Autism Spectrum Disorders (ASD). The new technology can nicely complement other models for basic research and the development of therapeutic compounds aiming to rever...

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Veröffentlicht in:	Experimental neurology 2014-10, Vol.260, p.33-43
Hauptverfasser:	Freitas, Beatriz C.G., Trujillo, Cleber A., Carromeu, Cassiano, Yusupova, Marianna, Herai, Roberto H., Muotri, Alysson R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angelman syndrome Animal model Animals Autism spectrum disorders Cell- and Tissue-Based Therapy - methods Child Development Disorders, Pervasive - genetics Child Development Disorders, Pervasive - therapy Disease Models, Animal Fragile X syndrome Genomic editing Humans Induced pluripotent stem cells Neurons - cytology Neurons - physiology Rett syndrome Rett Syndrome - genetics Rett Syndrome - therapy Stem cells Stem Cells - cytology Timothy syndrome
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Beschreibung
Zusammenfassung:	Human neurons, generated from reprogrammed somatic cells isolated from live patients, bring a new perspective on the understanding of Autism Spectrum Disorders (ASD). The new technology can nicely complement other models for basic research and the development of therapeutic compounds aiming to revert or ameliorate the condition. Here, we discuss recent advances on the use of stem cells and other models to study ASDs, as well as their limitations, implications and future perspectives.
ISSN:	0014-4886 1090-2430
DOI:	10.1016/j.expneurol.2012.09.017