Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility

Julius Gudmundsson and colleagues report a prostate cancer genome-wide association follow-on study. They report variants at 3q21.3, 8q24.21 and 19q13.2 newly associated to prostate cancer susceptibility and the fine-mapping of the association signal at 11q13. We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 × 10 −10 ) on 3q21.3; two moderately correlated ( r 2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 × 10 −15 ) and rs445114[T] (OR = 1.14, P = 4.7 × 10 −10 ), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 × 10 −11 ) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 × 10 −12 ). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.