Curcumin ameliorates arterial dysfunction and oxidative stress with aging

We tested the hypothesis that curcumin supplementation would reverse arterial dysfunction and vascular oxidative stress with aging. Young (Y, 4–6months) and old (O, 26–28months) male C57BL6/N mice were given normal or curcumin supplemented (0.2%) chow for 4weeks (n=5–10/group/measure). Large elastic...

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Veröffentlicht in:	Experimental gerontology 2013-02, Vol.48 (2), p.269-276
Hauptverfasser:	Fleenor, Bradley S., Sindler, Amy L., Marvi, Natasha K., Howell, Kate L., Zigler, Melanie L., Yoshizawa, Mutsuko, Seals, Douglas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors AGEs Aging - metabolism Animals Antioxidants - pharmacology Aorta - drug effects Aorta - metabolism Aorta - physiopathology Arterial stiffness Carotid Arteries - drug effects Carotid Arteries - metabolism Carotid Arteries - physiopathology Collagen Collagen Type I - metabolism Curcumin - pharmacology Dose-Response Relationship, Drug Elastin - metabolism Endothelial function Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Glycation End Products, Advanced - metabolism Male Mice Mice, Inbred C57BL Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Oxidative Stress - drug effects Phosphoproteins - metabolism Pulse Wave Analysis Superoxide Superoxide Dismutase - metabolism Superoxides - metabolism Tyrosine - analogs & derivatives Tyrosine - metabolism Vascular Stiffness - drug effects Vasodilation - drug effects Vasodilator Agents - pharmacology
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Zusammenfassung:	We tested the hypothesis that curcumin supplementation would reverse arterial dysfunction and vascular oxidative stress with aging. Young (Y, 4–6months) and old (O, 26–28months) male C57BL6/N mice were given normal or curcumin supplemented (0.2%) chow for 4weeks (n=5–10/group/measure). Large elastic artery stiffness, assessed by aortic pulse wave velocity (aPWV), was greater in O (448±15 vs. 349±15cm/s) and associated with greater collagen I and advanced glycation end-products and less elastin (all P
ISSN:	0531-5565 1873-6815
DOI:	10.1016/j.exger.2012.10.008