Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes

Aims/hypothesis The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear Maf...

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Veröffentlicht in:	Diabetologia 2012-11, Vol.55 (11), p.2985-2988
Hauptverfasser:	Butler, A. E., Robertson, R. P., Hernandez, R., Matveyenko, A. V., Gurlo, T., Butler, P. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Biological and medical sciences Blood & organ donations Blood Glucose - metabolism Cancer Cell Nucleus - metabolism Cells, Cultured Diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting Female Fibrosarcoma Glucagon Glucagon - metabolism Glucose Human Physiology Humans Hyperglycemia Hyperglycemia - metabolism Hyperglycemia - physiopathology Hypotheses Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - physiology Internal Medicine Laboratories Localization Maf Transcription Factors, Large - deficiency Maf Transcription Factors, Large - metabolism Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Pancreas Pancreatitis Rats Rats, Nude Short Communication Stem cells Surgery
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Zusammenfassung:	Aims/hypothesis The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear MafA is less abundant in beta cell nuclei in humans with type 2 diabetes. Methods Pancreas obtained at surgery from five non-diabetic individuals and six individuals with type 2 diabetes was immunostained for insulin, glucagon and MafA. Results Beta cell nuclear MafA was markedly decreased in type 2 diabetes (1.6 ± 1.2% vs 46.3 ± 8.3%, p
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-012-2666-2