Investigating the Binding Mode of an Inhibitor of the MBNL1⋅RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA-Selective Binder
Recognition made easy: The selectivity of a small‐molecule inhibitor that binds CTG and CUG sites with similar affinity can be shifted toward exclusive CTG recognition by a single N‐methylation. Biophysical studies and MD simulations provide insights into the DNA and RNA recognition.
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| Veröffentlicht in: | Chembiochem : a European journal of chemical biology 2012-11, Vol.13 (17), p.2505-2509 |
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| container_issue | 17 |
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| container_title | Chembiochem : a European journal of chemical biology |
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| creator | Wong, Chun-Ho Richardson, Stacie L. Ho, Yen-Jun Lucas, Alex M. H. Tuccinardi, Tiziano Baranger, Anne M. Zimmerman, Steven C. |
| description | Recognition made easy: The selectivity of a small‐molecule inhibitor that binds CTG and CUG sites with similar affinity can be shifted toward exclusive CTG recognition by a single N‐methylation. Biophysical studies and MD simulations provide insights into the DNA and RNA recognition. |
| doi_str_mv | 10.1002/cbic.201200602 |
| format | Article |
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| ispartof | Chembiochem : a European journal of chemical biology, 2012-11, Vol.13 (17), p.2505-2509 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Base Sequence DNA DNA - chemistry DNA - genetics DNA - metabolism drug design Drug Discovery Genetic Therapy inhibitors Ligands Molecular Dynamics Simulation Myotonic Dystrophy - genetics Myotonic Dystrophy - metabolism Myotonic Dystrophy - therapy Nucleic Acid Conformation Protein Binding - drug effects recognition RNA RNA - chemistry RNA - genetics RNA - metabolism RNA-Binding Proteins - metabolism Substrate Specificity Trinucleotide Repeats |
| title | Investigating the Binding Mode of an Inhibitor of the MBNL1⋅RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA-Selective Binder |
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