Investigating the Binding Mode of an Inhibitor of the MBNL1⋅RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA-Selective Binder

Investigating the Binding Mode of an Inhibitor of the MBNL1⋅RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA-Selective Binder

Recognition made easy: The selectivity of a small‐molecule inhibitor that binds CTG and CUG sites with similar affinity can be shifted toward exclusive CTG recognition by a single N‐methylation. Biophysical studies and MD simulations provide insights into the DNA and RNA recognition.

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Bibliographische Detailangaben
Veröffentlicht in:Chembiochem : a European journal of chemical biology 2012-11, Vol.13 (17), p.2505-2509
Hauptverfasser: Wong, Chun-Ho, Richardson, Stacie L., Ho, Yen-Jun, Lucas, Alex M. H., Tuccinardi, Tiziano, Baranger, Anne M., Zimmerman, Steven C.
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
DNA
DNA - chemistry
DNA - genetics
DNA - metabolism
drug design
Drug Discovery
Genetic Therapy
inhibitors
Ligands
Molecular Dynamics Simulation
Myotonic Dystrophy - genetics
Myotonic Dystrophy - metabolism
Myotonic Dystrophy - therapy
Nucleic Acid Conformation
Protein Binding - drug effects
recognition
RNA
RNA - chemistry
RNA - genetics
RNA - metabolism
RNA-Binding Proteins - metabolism
Substrate Specificity
Trinucleotide Repeats
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Zusammenfassung:Recognition made easy: The selectivity of a small‐molecule inhibitor that binds CTG and CUG sites with similar affinity can be shifted toward exclusive CTG recognition by a single N‐methylation. Biophysical studies and MD simulations provide insights into the DNA and RNA recognition.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201200602