Immunity to seasonal and pandemic influenza A viruses

The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic var...

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Veröffentlicht in:	Microbes and infection 2011-05, Vol.13 (5), p.489-501
Hauptverfasser:	Valkenburg, Sophie A., Rutigliano, John A., Ellebedy, Ali H., Doherty, Peter C., Thomas, Paul G., Kedzierska, Katherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Antibodies, Viral - immunology Antigenic variation CD8-Positive T-Lymphocytes - immunology H1N1 2009 Humans Immunity, Innate Influenza A virus - classification Influenza A virus - immunology Influenza A Virus, H1N1 Subtype - immunology Influenza virus Influenza, Human - immunology Influenza, Human - virology Innate immunity Mice Pandemics Seasons
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Beschreibung
Zusammenfassung:	The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic variation within T-cell immunogenic peptides and our understanding of pre-existing immunity towards the pandemic A(H1N1) 2009 strain.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2011.01.007