Cytokines and brain excitability

Cytokines and brain excitability

Highlights ► Cytokines are produced in brain in response to a peripheral or brain inflammation. ► Cytokines are also produced during seizure activity. ► Cytokines augment seizure activity and may be important in epileptogenesis. ► Cytokines upregulate glutamatergic and downregulate GABAergic synapse...

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Veröffentlicht in:Frontiers in neuroendocrinology 2012-01, Vol.33 (1), p.116-125
Hauptverfasser: Galic, Michael A, Riazi, Kiarash, Pittman, Quentin J
Format: Artikel
Sprache:eng
Schlagworte:
Akathisia, Drug-Induced
Animals
Brain - metabolism
Chemokine
Cytokine
Cytokines - physiology
Down-Regulation
Endocrinology & Metabolism
Epilepsy
Epilepsy - physiopathology
Febrile convulsion
gamma-Aminobutyric Acid - physiology
Humans
Inflammation
Inflammation - physiopathology
Interleukin
Lipopolysaccharide
Neurons - drug effects
Neurons - physiology
Psychomotor Agitation - etiology
Seizure
Seizures - immunology
Synapse
Synaptic Transmission - drug effects
Tumor necrosis factor α
Up-Regulation
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Beschreibung
Zusammenfassung:Highlights ► Cytokines are produced in brain in response to a peripheral or brain inflammation. ► Cytokines are also produced during seizure activity. ► Cytokines augment seizure activity and may be important in epileptogenesis. ► Cytokines upregulate glutamatergic and downregulate GABAergic synapses.
ISSN:0091-3022
1095-6808
DOI:10.1016/j.yfrne.2011.12.002