Fatal poisoning by isoniazid and rifampicin

Fatal poisoning by isoniazid and rifampicin

Isoniazid and rifampicin are used for management of tuberculosis. Acute poisoning due to isoniazid overdose is associated with repetitive generalized tonic-clonic seizures and severe metabolic acidosis. In toxic doses, rifampicin is known to produce hepatic, renal, hematological disorders, and convu...

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Veröffentlicht in:Indian journal of nephrology 2012-09, Vol.22 (5), p.385-387
Hauptverfasser: Sridhar, A, Sandeep, Y, Krishnakishore, C, Sriramnaveen, P, Manjusha, Y, Sivakumar, V
Format: Artikel
Sprache:eng
Schlagworte:
Acidosis
Case Report
Case studies
Complications and side effects
Dosage and administration
Drug therapy
Hyperglycemia
Isoniazid
Metabolites
Peritoneal dialysis
Rifampin
Risk factors
Seizures (Medicine)
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Zusammenfassung:Isoniazid and rifampicin are used for management of tuberculosis. Acute poisoning due to isoniazid overdose is associated with repetitive generalized tonic-clonic seizures and severe metabolic acidosis. In toxic doses, rifampicin is known to produce hepatic, renal, hematological disorders, and convulsions. Sometimes, it may produce red man syndrome. We report a case of fatal poisoning with isoniazid and rifampicin. The case was characterized by late presentation, lactic acidosis, and renal failure.
ISSN:0971-4065
1998-3662
DOI:10.4103/0971-4065.103930