PGC7, H3K9me2 and Tet3： regulators of DNA methylation in zygotes

In zygotes, a global loss of DNA methylation occurs selectively in the paternal pronucleus before the first cell division, concomitantly with the appearance of modified forms of 5-m- ethylcytosine. The adjacent maternal pronucleus and certain paternallyimprinted loci are protected from this process....

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Veröffentlicht in:	Cell research 2013-01, Vol.23 (1), p.6-9
Hauptverfasser:	Kang, Jinsuk, Kalantry, Sundeep, Rao, Anjana
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/176/1988 631/443/494 Animals Biomedical and Life Sciences Cell Biology Cell division Deoxyribonucleic acid DNA DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA甲基化 Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryonic Development Female Genomes Histones Histones - genetics Histones - metabolism Life Sciences Lysine Male Mice Molecular modelling pronucleus Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Research Highlight Zygote - cytology Zygote - metabolism Zygotes 分子机制原核受精卵监管机构组蛋白细胞分裂赖氨酸
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Beschreibung
Zusammenfassung:	In zygotes, a global loss of DNA methylation occurs selectively in the paternal pronucleus before the first cell division, concomitantly with the appearance of modified forms of 5-m- ethylcytosine. The adjacent maternal pronucleus and certain paternallyimprinted loci are protected from this process. Nakamura et al. recently clarified the molecular mechanism involved： PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9 （H3K9me2）,
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2012.117