The dawn of angiogenesis modeling： regenerating vasculature from human pluripotent stem cells

Efficient generation of functional human vascular endothelial cells and smooth muscle cells from pluripotent stem cells is an extensively studied topic and of great interest in the stem cell field. Though thought to be technically complex and difficult, substantial progress has been made towards thi...

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Veröffentlicht in:	Cell research 2013-01, Vol.23 (1), p.3-5
Hauptverfasser:	Yi, Fei, Qu, Jing, Liu, Guang-Hui, Belmonte, Juan Carlos Izpisua
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/592/16 631/532/2064 631/532/489 Biomedical and Life Sciences Cell Biology Cell Differentiation Endothelial Cells - cytology Humans Life Sciences Models, Biological Myocytes, Smooth Muscle - cytology Neovascularization, Physiologic - physiology Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Receptors, Urokinase Plasminogen Activator - metabolism Regeneration Research Highlight Stem cells 人类多能干细胞多能性平滑肌细胞生成模型血管内皮细胞血管再生
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Zusammenfassung:	Efficient generation of functional human vascular endothelial cells and smooth muscle cells from pluripotent stem cells is an extensively studied topic and of great interest in the stem cell field. Though thought to be technically complex and difficult, substantial progress has been made towards this direction. Here we aim to summarize and discuss the most recent advances in this topic and their future perspective in research and clinic.
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2012.131