Whole blood is the sample matrix of choice for monitoring systemic triclocarban levels

The antibacterial triclocarban (TCC) concentrates in the cellular fraction of blood. Consequently, plasma levels are at least two-fold lower than the TCC amount present in blood. Utilizing whole blood sampling, a low but significant absorption of TCC from soap during showering is demonstrated for a...

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Veröffentlicht in:	Chemosphere (Oxford) 2012-05, Vol.87 (7), p.825-827
Hauptverfasser:	Schebb, Nils Helge, Ahn, Ki Chang, Dong, Hua, Gee, Shirley J., Hammock, Bruce D.
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption analysis Animals Anti-Infective Agents, Local Anti-Infective Agents, Local - blood Antibacterial Biological and medical sciences Biomonitoring blood Blood Chemical Analysis Blood Chemical Analysis - methods blood sampling Carbanilides Carbanilides - blood Domestic and cosmetic products toxicology Environmental Exposure Environmental Exposure - analysis humans Male Medical sciences methods Mice monitoring soaps Toxicology Triclocarban Whole blood
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Beschreibung
Zusammenfassung:	The antibacterial triclocarban (TCC) concentrates in the cellular fraction of blood. Consequently, plasma levels are at least two-fold lower than the TCC amount present in blood. Utilizing whole blood sampling, a low but significant absorption of TCC from soap during showering is demonstrated for a small group of human subjects.
ISSN:	0045-6535 1879-1298
DOI:	10.1016/j.chemosphere.2011.12.077