LKB1 and AMP‐activated protein kinase: regulators of cell polarity

Adenosine monophosphate–activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polar...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes to cells : devoted to molecular & cellular mechanisms 2012-09, Vol.17 (9), p.737-747
Hauptverfasser:	Nakano, Atsushi, Takashima, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - physiology Animals Caenorhabditis elegans - enzymology Caenorhabditis elegans - physiology Cell Movement Cell Polarity Cell Shape Drosophila - enzymology Drosophila - genetics Drosophila - physiology Drosophila Proteins - genetics Drosophila Proteins - physiology Gene Expression Regulation, Enzymologic Mammals - genetics Mammals - physiology Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - physiology Microtubules - physiology Neoplasm Proteins - genetics Neoplasm Proteins - physiology Phosphorylation Protein Kinases - genetics Protein Kinases - physiology Review
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Adenosine monophosphate–activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polarity are relatively well conserved. Here, we review the mechanisms and factors responsible for organizing cell polarity and the role of LKB1 and AMPK in cell polarity.
ISSN:	1356-9597 1365-2443
DOI:	10.1111/j.1365-2443.2012.01629.x