Versatile approach to α-alkoxy carbamate synthesis and stimulus-responsive alcohol release

Versatile approach to α-alkoxy carbamate synthesis and stimulus-responsive alcohol release

A series of α-alkoxy carbamates that cleave under mild conditions to release alcohols has been synthesized through a multicomponent process. The relationship between structural features in these compounds and the rate of alcohol release in the presence of basic hydrogen peroxide has been studied. Th...

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Veröffentlicht in:Organic & biomolecular chemistry 2012-10, Vol.10 (39), p.7980-7985
Hauptverfasser: Mosey, R Adam, Floreancig, Paul E
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols - chemistry
Carbamates - chemical synthesis
Carbamates - chemistry
Hydrogen Peroxide - chemistry
Molecular Structure
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Zusammenfassung:A series of α-alkoxy carbamates that cleave under mild conditions to release alcohols has been synthesized through a multicomponent process. The relationship between structural features in these compounds and the rate of alcohol release in the presence of basic hydrogen peroxide has been studied. The preparation of carbamates that cleave under other conditions has been demonstrated.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob26571k