The SirT3 Divining Rod Points to Oxidative Stress

Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative str...

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Veröffentlicht in:	Molecular cell 2011-06, Vol.42 (5), p.561-568
Hauptverfasser:	Bell, Eric L., Guarente, Leonard
Format:	Artikel
Sprache:	eng
Schlagworte:	aerobiosis Animals Caloric Restriction Cell Line Hearing Loss - etiology Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice mitochondria Mitochondria - metabolism Oxidative Stress reactive oxygen species Reactive Oxygen Species - metabolism Sirtuin 3 - physiology transcription factors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - physiology
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Beschreibung
Zusammenfassung:	Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative stress. This review focuses on new data linking SirT3 to management of reactive oxygen species from mitochondria, which may have profound implications for aging and late-onset diseases.
ISSN:	1097-2765 1097-4164
DOI:	10.1016/j.molcel.2011.05.008