The importance of Rho-associated kinase-induced Ca2+ sensitization as a component of electromechanical and pharmacomechanical coupling in rat ureteric smooth muscle

The importance of Rho-associated kinase-induced Ca2+ sensitization as a component of electromechanical and pharmacomechanical coupling in rat ureteric smooth muscle

Highlights ► RhoA/Rho-kinase in ureteric smooth muscle. ► ROK-catalyzed phosphorylation of MYPT1 at T855 is playing a key role in control of MLCP activity and LC20 phosphorylation in rat ureteric smooth muscle. ► Inhibition of ROK leads to an increase in the activity of MLCP, selective inhibition of...

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Veröffentlicht in:Cell calcium (Edinburgh) 2011-10, Vol.50 (4), p.393-405
Hauptverfasser: Borysova, Lyudmyla, Shabir, S, Walsh, Michael P, Burdyga, Theodor
Format: Artikel
Sprache:eng
Schlagworte:
Action Potentials - drug effects
Advanced Basic Science
Animals
Ca2+ sensitization
Calcium - metabolism
Calcium Signaling - drug effects
Calcium Signaling - physiology
Carbachol - pharmacology
Enzyme Activation
Kidney - physiology
Mechanical Phenomena
Muscle Contraction - drug effects
Muscle Contraction - physiology
Muscle, Smooth - cytology
Muscle, Smooth - drug effects
Muscle, Smooth - physiology
Myosin Light Chains - metabolism
Myosin-Light-Chain Phosphatase - metabolism
Phosphorylation - drug effects
Protein Phosphatase 1 - antagonists & inhibitors
Protein Phosphatase 1 - metabolism
Rats
rho-Associated Kinases - metabolism
Rho-kinase
Sodium Chloride - pharmacology
Ureter - cytology
Ureter - physiology
Ureter smooth muscle
Urinary Bladder - physiology
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Beschreibung
Zusammenfassung:Highlights ► RhoA/Rho-kinase in ureteric smooth muscle. ► ROK-catalyzed phosphorylation of MYPT1 at T855 is playing a key role in control of MLCP activity and LC20 phosphorylation in rat ureteric smooth muscle. ► Inhibition of ROK leads to an increase in the activity of MLCP, selective inhibition of tonic and acceleration of relaxation of phasic component of KCL- and CCh induced contracture.
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2011.07.003