SNCA variants are associated with increased risk for multiple system atrophy

To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome‐wide association study of Parkinson's dis...

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Veröffentlicht in:Annals of neurology 2009-05, Vol.65 (5), p.610-614
Hauptverfasser: Scholz, Sonja W., Houlden, Henry, Schulte, Claudia, Sharma, Manu, Li, Abi, Berg, Daniela, Melchers, Anna, Paudel, Reema, Gibbs, J. Raphael, Simon-Sanchez, Javier, Paisan-Ruiz, Coro, Bras, Jose, Ding, Jinhui, Chen, Honglei, Traynor, Bryan J., Arepalli, Sampath, Zonozi, Ryan R., Revesz, Tamas, Holton, Janice, Wood, Nick, Lees, Andrew, Oertel, Wolfgang, Wüllner, Ullrich, Goldwurm, Stefano, Pellecchia, Maria Teresa, Illig, Thomas, Riess, Olaf, Fernandez, Hubert H., Rodriguez, Ramon L., Okun, Michael S., Poewe, Werner, Wenning, Gregor K., Hardy, John A., Singleton, Andrew B., Gasser, Thomas
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Sprache:eng
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Zusammenfassung:To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome‐wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 × 1012; odds ratio 6.2). Ann Neurol 2009;65:610–614
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.21685