NY-ESO-1 expression in sarcomas: A diagnostic marker and immunotherapy target

NY-ESO-1 expression in sarcomas: A diagnostic marker and immunotherapy target

NY-ESO-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ESO-1 in the differential diagnosis of these lesions. Furthermore,...

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Veröffentlicht in:Oncoimmunology 2012-11, Vol.1 (8), p.1409-1410
Hauptverfasser: Lai, Jin-Ping, Rosenberg, Avi Z., Miettinen, Markku M., Lee, Chyi-Chia R.
Format: Artikel
Sprache:eng
Schlagworte:
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Binding
Biology
Bioscience
Calcium
Cancer
cancer-testis antigen
Cell
clinical trial
Cycle
diagnostic marker
immunotherapy
Landes
melanoma
NY-ESO-1
Organogenesis
Proteins
sarcomas
synovial sarcoma
T-cell receptor
therapeutic target
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Beschreibung
Zusammenfassung:NY-ESO-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ESO-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ESO-1-targeted immunotherapy in subsets of melanoma and synovial sarcoma patients.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.21059