Enantioselective reduction of ketones and imines catalyzed by (CN-box)Re(V)-oxo complexes

Enantioselective reduction of ketones and imines catalyzed by (CN-box)Re(V)-oxo complexes

The development and application of chiral, non-racemic Re(V)-oxo complexes to the enantioselective reduction of prochiral ketones is described. In addition to the enantioselective reduction of prochiral ketones, we report the application of these complexes to 1) a tandem Meyer-Schuster rearrangement...

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Veröffentlicht in:Chemistry : a European journal 2010-08, Vol.16 (31), p.9555-9562
Hauptverfasser: Nolin, Kristine A, Ahn, Richard W, Kobayashi, Yusuke, Kennedy-Smith, Joshua J, Toste, F Dean
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Cyanides - chemistry
Imines - chemistry
Ketones - chemistry
Molecular Structure
Oxidation-Reduction
Stereoisomerism
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Zusammenfassung:The development and application of chiral, non-racemic Re(V)-oxo complexes to the enantioselective reduction of prochiral ketones is described. In addition to the enantioselective reduction of prochiral ketones, we report the application of these complexes to 1) a tandem Meyer-Schuster rearrangement/reduction to access enantioenriched allylic alcohols and 2) the enantioselective reduction of imines.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201001164