Neuroendocrine carcinoma of the pancreas with soft tissue metastasis

Neuroendocrine carcinoma （NEC） of the pancreas is rare. We report the case of a 34-year-old man with pancreatic NEC with soft tissue metastasis. The pa- tient presented with right upper abdominal discomfort. Computed tomography revealed a low-density hetero- geneous mass in the tail and body of the pancreas that encroached on the greater curvature of the stomach and spleen. We performed exploratory laparotomy and total pancreatectomy with splenectomy and total gas- trectomy. Histopathological analysis showed spindle- shaped cells with scanty cytoplasm and hyperchromatic nuclei, confirming a primary pancreatic NEC. One month after the surgery, the patient experienced leg swelling. Positron emission tomography-computed tomography revealed high uptake of fludeoxyglucose in the left leg, and the leg was amputated. Histopathological analysis confirmed metastasis of pancreatic NEC. The patient was followed up and received chemotherapy （etoposide and cisplatin）. One month after amputation, the level of tumor marker neuron-specific enolase was 142.70 μg/L and computed tomography scan revealed an aggravated metastatic lesion. The patient suffered from unbearable pain and we treated him with odynolysis. Four months postoperatively, the patient died of respiratory failure.