The roles of purinergic signaling during gastrointestinal inflammation

Highlights ► Purinergic signaling in the gut is remarkably plastic and compartmentalized. ► Inflammation decreases purinergic neurovascular and neuromuscular transmission. ► Purine release from immune and epithelial cells is increased in colitis. ► P2X7 receptor and pannexin channel activation in co...

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Veröffentlicht in:	Current opinion in pharmacology 2012-12, Vol.12 (6), p.659-666
Hauptverfasser:	Roberts, Jane A, Lukewich, Mark K, Sharkey, Keith A, Furness, John B, Mawe, Gary M, Lomax, Alan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - physiopathology Gastrointestinal Tract - physiology Gastrointestinal Tract - physiopathology Humans Inflammation - drug therapy Inflammation - physiopathology Internal Medicine Medical Education Molecular Targeted Therapy Neurons - metabolism Paracrine Communication Purines - metabolism Receptors, Purinergic - metabolism Receptors, Purinergic P2X7 - metabolism Signal Transduction
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Beschreibung
Zusammenfassung:	Highlights ► Purinergic signaling in the gut is remarkably plastic and compartmentalized. ► Inflammation decreases purinergic neurovascular and neuromuscular transmission. ► Purine release from immune and epithelial cells is increased in colitis. ► P2X7 receptor and pannexin channel activation in colitis leads to neuronal loss. ► Inflammation-induced nociception involves spinal afferent P2X receptor activation.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2012.09.011