Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats

Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oxidative medicine and cellular longevity 2012-01, Vol.2012 (2012), p.1-7
Hauptverfasser:	Zepeda, Andrea, Aguayo, Luis G., Fuentealba, Jorge, Figueroa, Carolina, Acevedo, Alejandro, Salgado, Perla, Calaf, Gloria M., Farías, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blueberry Plants - chemistry Body Weight - drug effects Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Hematocrit Hypoxia - enzymology Hypoxia - pathology Hypoxia - prevention & control Lipid Peroxidation - drug effects Male Organ Size - drug effects Oxidative Stress - drug effects Plant Extracts - pharmacology Protective Agents - pharmacology Rats Rats, Sprague-Dawley Superoxide Dismutase - metabolism Testis - drug effects Testis - enzymology Testis - pathology Thiobarbituric Acid Reactive Substances - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Exposure to hypobaric hypoxia causes oxidative damage to male rat reproductive function. The aim of this study was to evaluate the protective effect of a blueberry extract (BB-4) in testis of rats exposed to hypobaric hypoxia. Morphometric analysis, cellular DNA fragmentation, glutathione reductase (GR), and superoxide dismutase (SOD) activities were evaluated. Our results showed that supplementation of BB-4 reduced lipid peroxidation, decreased apoptosis, and increased GR and SOD activities in rat testis under hypobaric hypoxia conditions (P
ISSN:	1942-0900 1942-0994
DOI:	10.1155/2012/975870