Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for the motor symptoms of Parkinson's disease (PD). The effects of DBS depend strongly on stimulation frequency: high frequencies (>90 Hz) improve motor symptoms, while low frequencies (

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2012-11, Vol.32 (45), p.15657-15668
Hauptverfasser:	McConnell, George C, So, Rosa Q, Hilliard, Justin D, Lopomo, Paola, Grill, Warren M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Basal Ganglia - physiopathology Behavior, Animal - physiology Deep Brain Stimulation Female Motor Activity - physiology Nerve Net - physiopathology Neurons - physiology Oxidopamine Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - physiopathology Rats Rats, Long-Evans
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Beschreibung
Zusammenfassung:	Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for the motor symptoms of Parkinson's disease (PD). The effects of DBS depend strongly on stimulation frequency: high frequencies (>90 Hz) improve motor symptoms, while low frequencies (
ISSN:	0270-6474 1529-2401 1529-2401
DOI:	10.1523/JNEUROSCI.2824-12.2012