Nanoblade Delivery and Incorporation of Quantum Dot Conjugates into Tubulin Networks in Live Cells

Quantum dots (QDs) have not been used to label cytoskeleton structure of live cells owing to limitations in delivery strategies, and QDs conjugation methods and issues with nonspecific binding. We conjugated tubulin to QDs and applied the emerging method of photothermal nanoblade to deliver QD-tubul...

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Veröffentlicht in:	Nano letters 2012-11, Vol.12 (11), p.5669-5672
Hauptverfasser:	Xu, Jianmin, Teslaa, Tara, Wu, Ting-Hsiang, Chiou, Pei-Yu, Teitell, Michael A, Weiss, Shimon
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Binding Conjugates Conjugation Cross-disciplinary physics: materials science rheology Cytoskeleton - metabolism Cytosol - metabolism Drug Delivery Systems Electronics Endosomes - chemistry Exact sciences and technology HeLa Cells Humans Labels Light Materials science Microscopy - methods Molecular electronics, nanoelectronics Nanocrystalline materials Nanoscale materials and structures: fabrication and characterization Nanostructure Nanotechnology - methods Networks Photochemistry - methods Physics Quantum Dots Semiconductor electronics. Microelectronics. Optoelectronics. Solid state devices Strategy Tubulin - chemistry
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Beschreibung
Zusammenfassung:	Quantum dots (QDs) have not been used to label cytoskeleton structure of live cells owing to limitations in delivery strategies, and QDs conjugation methods and issues with nonspecific binding. We conjugated tubulin to QDs and applied the emerging method of photothermal nanoblade to deliver QD-tubulin conjugates into live Hela cells. This method will open new opportunities for cytosolic targeting of QDs in live cells.
ISSN:	1530-6984 1530-6992
DOI:	10.1021/nl302821g