Immunological regulation of neurogenic niches in the adult brain

Graphical abstract Highlights ► Proinflammatory cytokines are involved in the pathogenesis of neurological disorders. ► Cytokines and immune mediators regulate neurogenic niches in the adult brain. ► Neuroinflammation can limit the therapeutic use of grafted neural stem cells (NSCs). ► However, neur...

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Veröffentlicht in:	Neuroscience 2012-12, Vol.226, p.270-281
Hauptverfasser:	Gonzalez-Perez, O, Gutierrez-Fernandez, F, Lopez-Virgen, V, Collas-Aguilar, J, Quinones-Hinojosa, A, Garcia-Verdugo, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Brain - cytology Brain - immunology Central nervous system Chemokines - physiology cytokine Cytokines - physiology Fundamental and applied biological sciences. Psychology Humans inflammation interleukin microglia neural stem cells Neural Stem Cells - physiology Neurodegenerative Diseases - physiopathology Neurogenesis - immunology Neurogenesis - physiology Neurology subventricular zone Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Graphical abstract Highlights ► Proinflammatory cytokines are involved in the pathogenesis of neurological disorders. ► Cytokines and immune mediators regulate neurogenic niches in the adult brain. ► Neuroinflammation can limit the therapeutic use of grafted neural stem cells (NSCs). ► However, neuroinflammation can also promote the regenerative potential of NSCs. ► Stem-cell-based therapies should involve the regulation of immune system mediators.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.08.053