Estrous cycle variations in GABAA receptor phosphorylation enable rapid modulation by anabolic androgenic steroids in the medial preoptic area

Highlights ► GABAA receptor phosphorylation was higher in diestrus/proestrus than in estrus. ► AAS elicited rapid enhancement of synaptic currents in diestrus, but not in estrus. ► Effects of AAS in diestrus were blocked by PKC inhibition. ► Levels of GABAA receptor subunit mRNAs did not vary across...

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Veröffentlicht in:	Neuroscience 2012-12, Vol.226, p.397-410
Hauptverfasser:	Oberlander, J.G, Porter, D.M, Onakomaiya, M.M, Penatti, C.A.A, Vithlani, M, Moss, S.J, Clark, A.S, Henderson, L.P
Format:	Artikel
Sprache:	eng
Schlagworte:	anabolic steroid Biological and medical sciences Fundamental and applied biological sciences. Psychology GABAA receptor inhibitory postsynaptic current medial preoptic area Neurology phosphorylation PKC Steroid hormones. Cholecalciferol derivatives Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	Highlights ► GABAA receptor phosphorylation was higher in diestrus/proestrus than in estrus. ► AAS elicited rapid enhancement of synaptic currents in diestrus, but not in estrus. ► Effects of AAS in diestrus were blocked by PKC inhibition. ► Levels of GABAA receptor subunit mRNAs did not vary across the estrous cycle. ► Single AAS injections impaired an mPOA-mediated behavior in diestrus, but not in estrus.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.09.014