Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules

Highlights ► Mouse cortical neurons were exposed to NMDA and a panel of neuroprotective molecules. ► Changes in whole genome expression were assessed by microarray analysis. ► Database mining and systems modeling identified common gene expression signatures. ► These included MAPK, TLR, HIF, adhesion...

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Veröffentlicht in:	Neuroscience 2012-12, Vol.226, p.10-20
Hauptverfasser:	Pappas, D.J, Gabatto, P.A, Oksenberg, D, Khankhanian, P, Baranzini, S.E, Gan, L, Oksenberg, J.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Calcium - metabolism Cell Adhesion - physiology Cell Survival - drug effects Cell Survival - physiology Central nervous system Cerebral Cortex - cytology Cerebral Cortex - drug effects Data Mining excitotoxicity Fundamental and applied biological sciences. Psychology Gene Library Genome-Wide Association Study glutamate Glutamic Acid - metabolism Glutamic Acid - physiology Hypoxia-Inducible Factor 1 - biosynthesis Mice microarray Mitogen-Activated Protein Kinases - physiology Neurology neuron Neurons - drug effects Neurons - metabolism neuroprotection Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology NMDA Real-Time Polymerase Chain Reaction Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - physiology RNA Interference Signal Transduction - genetics Signal Transduction - physiology Toll-Like Receptors - biosynthesis Transcription, Genetic - drug effects Transcriptome Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► Mouse cortical neurons were exposed to NMDA and a panel of neuroprotective molecules. ► Changes in whole genome expression were assessed by microarray analysis. ► Database mining and systems modeling identified common gene expression signatures. ► These included MAPK, TLR, HIF, adhesion, and nucleic acid repair genes and pathways. ► Chemically divergent molecules converged at the level of whole genome transcription.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.09.007