Cross-sensitization of histamine-independent itch in mouse primary sensory neurons

Highlights ► MrgprC11 agonist BAM8-22 cross-sensitized scratching evoked by PAR-2 agonist. ► MrgprA3 agonist chloroquine cross-sensitized BAM8-22-evoked scratching. ► Histamine cross-sensitized chloroquine- and BAM8-22-evoked scratching. ► PAR-2 agonist cross-sensitized chloroquine-evoked scratching...

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Veröffentlicht in:	Neuroscience 2012-12, Vol.226, p.305-312
Hauptverfasser:	Akiyama, T, Tominaga, M, Davoodi, A, Nagamine, M, Blansit, K, Horwitz, A, Carstens, M.I, Carstens, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences calcium imaging Calcium Signaling - physiology Chloroquine cross-sensitization Dermatology dorsal root ganglion (DRG) cell Ganglia, Spinal - cytology Ganglia, Spinal - physiology Histamine - physiology itch Male Medical sciences Mice Mice, Inbred C57BL Neuroimaging Neurology Peptide Fragments pruritogen Pruritus - chemically induced Pruritus - physiopathology Pruritus - psychology Receptor, PAR-2 - agonists scratching Sensory Receptor Cells - drug effects Sensory Receptor Cells - physiology Signal Transduction - physiology Skin involvement in other diseases. Miscellaneous. General aspects
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Zusammenfassung:	Highlights ► MrgprC11 agonist BAM8-22 cross-sensitized scratching evoked by PAR-2 agonist. ► MrgprA3 agonist chloroquine cross-sensitized BAM8-22-evoked scratching. ► Histamine cross-sensitized chloroquine- and BAM8-22-evoked scratching. ► PAR-2 agonist cross-sensitized chloroquine-evoked scratching and DRG cell responses. ► PAR-2 is a peripheral target to reduce sensitization associated with chronic itch.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.09.019