Age-dependent effects of carotid endarterectomy or stenting on cognitive performance

Although evidence is accumulating that age modifies the risk of carotid angioplasty and stenting (CAS) versus endarterectomy (CEA) for patients with significant carotid stenosis, the impact of age on cognition after either CEA or CAS remains unclear. In this study, we analyzed the effects of age on...

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Veröffentlicht in:	Journal of neurology 2012-11, Vol.259 (11), p.2309-2318
Hauptverfasser:	Wasser, Katrin, Hildebrandt, Helmut, Gröschel, Sonja, Stojanovic, Tomislav, Schmidt, Holger, Gröschel, Klaus, Pilgram-Pastor, Sara M., Knauth, Michael, Kastrup, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Aged Angioplasty Angioplasty, Balloon - adverse effects Angioplasty, Balloon - psychology Asymptomatic Biological and medical sciences Carcinoembryonic antigen Carotid arteries Carotid Stenosis - epidemiology Carotid Stenosis - psychology Carotid Stenosis - surgery Cognition & reasoning Cognition Disorders - epidemiology Cognition Disorders - psychology Cognitive ability Endarterectomy, Carotid - adverse effects Endarterectomy, Carotid - psychology Female Humans Ischemia Learning Magnetic resonance imaging Male Medical sciences Medicine Medicine & Public Health Middle Aged Neurology Neuropharmacology Neuroprotective agent Neuropsychological Tests Neuropsychology Neuroradiology Neurosciences Original Communication Pharmacology. Drug treatments Retrospective Studies Stenosis Stents - adverse effects Treatment Outcome Ultrasonic imaging Veins & arteries
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Zusammenfassung:	Although evidence is accumulating that age modifies the risk of carotid angioplasty and stenting (CAS) versus endarterectomy (CEA) for patients with significant carotid stenosis, the impact of age on cognition after either CEA or CAS remains unclear. In this study, we analyzed the effects of age on cognitive performance after either CEA or CAS using a comprehensive neuropsychological test battery with parallel test forms and a control group to exclude a learning effect. The neuropsychological outcomes after revascularization were determined in 19 CAS and 27 CEA patients with severe carotid stenosis. The patients were subdivided according to their median age (
ISSN:	0340-5354 1432-1459
DOI:	10.1007/s00415-012-6491-9