Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood
Platelets are a paradigm for a drug carrier in blood owing to their unique physical and biochemical properties. Here, we report the development of synthetic particles that mimic several physical features and important functional properties of platelets. These synthetic platelets have therapeutic and...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2012-07, Vol.24 (28), p.3864-3869 |
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| container_end_page | 3869 |
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| container_issue | 28 |
| container_start_page | 3864 |
| container_title | Advanced materials (Weinheim) |
| container_volume | 24 |
| creator | Doshi, Nishit Orje, Jennifer N. Molins, Blanca Smith, Jeffrey W. Mitragotri, Samir Ruggeri, Zaverio M. |
| description | Platelets are a paradigm for a drug carrier in blood owing to their unique physical and biochemical properties. Here, we report the development of synthetic particles that mimic several physical features and important functional properties of platelets. These synthetic platelets have therapeutic and diagnostic applications for platelet associated disorders. |
| doi_str_mv | 10.1002/adma.201200607 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0935-9648 |
| ispartof | Advanced materials (Weinheim), 2012-07, Vol.24 (28), p.3864-3869 |
| issn | 0935-9648 1521-4095 |
| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | Artificial Cells - chemistry Artificial Cells - ultrastructure Biomimetic Materials - chemistry Biomimetic Materials - therapeutic use Blood Platelets - physiology Blood Platelets - ultrastructure GPIb Humans In Vitro Techniques layer-by-layer technique Microscopy, Electron, Scanning Particle Size Platelet Aggregation platelets polymeric particles targeted drug delivery Thrombosis - blood Thrombosis - therapy VWF domain |
| title | Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood |
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