Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood

Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood

Platelets are a paradigm for a drug carrier in blood owing to their unique physical and biochemical properties. Here, we report the development of synthetic particles that mimic several physical features and important functional properties of platelets. These synthetic platelets have therapeutic and...

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Veröffentlicht in:Advanced materials (Weinheim) 2012-07, Vol.24 (28), p.3864-3869
Hauptverfasser: Doshi, Nishit, Orje, Jennifer N., Molins, Blanca, Smith, Jeffrey W., Mitragotri, Samir, Ruggeri, Zaverio M.
Format: Artikel
Sprache:eng
Schlagworte:
Artificial Cells - chemistry
Artificial Cells - ultrastructure
Biomimetic Materials - chemistry
Biomimetic Materials - therapeutic use
Blood Platelets - physiology
Blood Platelets - ultrastructure
GPIb
Humans
In Vitro Techniques
layer-by-layer technique
Microscopy, Electron, Scanning
Particle Size
Platelet Aggregation
platelets
polymeric particles
targeted drug delivery
Thrombosis - blood
Thrombosis - therapy
VWF domain
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Beschreibung
Zusammenfassung:Platelets are a paradigm for a drug carrier in blood owing to their unique physical and biochemical properties. Here, we report the development of synthetic particles that mimic several physical features and important functional properties of platelets. These synthetic platelets have therapeutic and diagnostic applications for platelet associated disorders.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201200607