Synaptic plasticity of NMDA receptors: mechanisms and functional implications

Highlights ► NMDARs exhibit diverse functional role based on their unique biophysical properties. ► We review current work describing activity-dependent plasticity of NMDAR transmission. ► NMDARs can by dynamically regulated by numerous induction and expression mechanisms. ► NMDAR plasticity is a po...

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Veröffentlicht in:	Current opinion in neurobiology 2012-06, Vol.22 (3), p.496-508
Hauptverfasser:	Hunt, David L, Castillo, Pablo E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biophysics Neurology Neuronal Plasticity - physiology Psychiatry Receptors, N-Methyl-D-Aspartate - physiology Synapses - physiology Synaptic Transmission - physiology
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Zusammenfassung:	Highlights ► NMDARs exhibit diverse functional role based on their unique biophysical properties. ► We review current work describing activity-dependent plasticity of NMDAR transmission. ► NMDARs can by dynamically regulated by numerous induction and expression mechanisms. ► NMDAR plasticity is a powerful means by which information can be encoded and stored.
ISSN:	0959-4388 1873-6882
DOI:	10.1016/j.conb.2012.01.007