Functional Analysis of an Aspartate-Based Epoxidation Catalyst with Amide-to-Alkene Peptidomimetic Catalyst Analogues

Subtle exchange: Replacement of an amide function with alkene or fluoroalkene groups provides a new class of epoxidation catalysts (see scheme). The structure‐dependent catalytic behavior of these isosteric peptides provides mechanistic insights in their mode of action.

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2008-01, Vol.47 (35), p.6707-6711
Hauptverfasser:	Jakobsche, Charles E, Peris, Gorka, Miller, Scott J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Amides - chemistry Aspartic Acid - chemistry asymmetric catalysis Biomimetic Materials - chemistry Catalysis epoxidation Epoxy Compounds - chemistry fluorine olefin isostere Oxidoreductases - chemistry peptides Peptides - chemistry peptidomimetic
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Beschreibung
Zusammenfassung:	Subtle exchange: Replacement of an amide function with alkene or fluoroalkene groups provides a new class of epoxidation catalysts (see scheme). The structure‐dependent catalytic behavior of these isosteric peptides provides mechanistic insights in their mode of action.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200802223