Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

Zebrafish larvae are particularly amenable to whole animal small molecule screens1,2 due to their small size and relative ease of manipulation and observation, as well as the fact that compounds can simply be added to the bathing water and are readily absorbed when administered in a

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of Visualized Experiments 2012-07 (65), p.e4203
Hauptverfasser:	Wittmann, Christine, Reischl, Markus, Shah, Asmi H., Mikut, Ralf, Liebel, Urban, Grabher, Clemens
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Drug Evaluation, Preclinical - instrumentation Drug Evaluation, Preclinical - methods Female High-Throughput Screening Assays - instrumentation High-Throughput Screening Assays - methods Immunology Inflammation - chemically induced Inflammation - drug therapy Inflammation - immunology Male Zebrafish
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Beschreibung
Zusammenfassung:	Zebrafish larvae are particularly amenable to whole animal small molecule screens1,2 due to their small size and relative ease of manipulation and observation, as well as the fact that compounds can simply be added to the bathing water and are readily absorbed when administered in a
ISSN:	1940-087X 1940-087X
DOI:	10.3791/4203