Gold nanoparticles as novel agents for cancer therapy

Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introduces the field of nanotechnology with a focus on recent gold nanoparticle research which has led to early-p...

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Veröffentlicht in:	British journal of radiology 2012-02, Vol.85 (1010), p.101-113
Hauptverfasser:	JAIN, S, HIRST, D. G, O'SULLIVAN, J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Contrast Media - administration & dosage Drug Carriers - administration & dosage Gold - pharmacology Gold - therapeutic use Humans Hyperthermia, Induced - methods Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Medical sciences Metal Nanoparticles - therapeutic use Mice Models, Biological Neoplasms - therapy Plasmids - drug effects Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - pharmacology Review Tomography, X-Ray Computed - methods
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Beschreibung
Zusammenfassung:	Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introduces the field of nanotechnology with a focus on recent gold nanoparticle research which has led to early-phase clinical trials. In particular, the pre-clinical evidence for gold nanoparticles as sensitisers with ionising radiation in vitro and in vivo at kilovoltage and megavoltage energies is discussed.
ISSN:	0007-1285 1748-880X
DOI:	10.1259/bjr/59448833