Relation between insufficient response to antihypertensive treatment and poor compliance with treatment: a prospective case-control study

Abstract Objectives: To prospectively compare compliance with treatment in patients with hypertension responsive to treatment versus patients with treatment resistant hypertension. Design: Prospective case-control study. Setting: Outpatient department in a large city hospital in Switzerland, providing primary, secondary, and tertiary care. Participants: 110 consecutive medical outpatients with hypertension and taking stable treatment with at least two antihypertensive drugs for at least four weeks. Main outcome measures: Treatment compliance assessed with MEMS devices; blood pressure determined by 12 hour daytime ambulatory monitoring (pressure