F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice

Highlights ► F-spondin gene transfer improves memory and lowers Aβ in wild-type mice. ► F-spondin upregulates synaptophysin and reduces Aβ plaques in AD-transgenic mice. ► First direct data of the effects of F-spondin elevation on neuropathology/behavior. ► Relevant for the development of therapies...

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Veröffentlicht in:	Neuroscience 2012-10, Vol.223, p.465-472
Hauptverfasser:	Hafez, D.M, Huang, J.Y, Richardson, J.C, Masliah, E, Peterson, D.A, Marr, R.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer’s disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics amyloid-beta Analysis of Variance Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Enzyme-Linked Immunosorbent Assay Exploratory Behavior - physiology Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Extracellular Matrix Proteins - therapeutic use F-spondin Fundamental and applied biological sciences. Psychology gene therapy Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors - physiology Green Fluorescent Proteins - genetics Humans Maze Learning - physiology Medical sciences Memory Disorders - etiology Memory Disorders - genetics Memory Disorders - therapy Mice Mice, Transgenic Mutation - genetics Neurology Peptide Fragments - metabolism Presenilin-1 - genetics reelin Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► F-spondin gene transfer improves memory and lowers Aβ in wild-type mice. ► F-spondin upregulates synaptophysin and reduces Aβ plaques in AD-transgenic mice. ► First direct data of the effects of F-spondin elevation on neuropathology/behavior. ► Relevant for the development of therapies for Alzheimer’s disease.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.07.038