Translation of DNA Signals into Polymer Assembly Instructions

We developed a DNA nanomechanical device that enables the positional synthesis of products whose sequences are determined by the state of the device. This machine emulates the translational capabilities of the ribosome. The device has been prototyped to make specific DNA sequences. The state of the...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-12, Vol.306 (5704), p.2072-2074
Hauptverfasser:	Liao, Shiping, Seeman, Nadrian C
Format:	Artikel
Sprache:	eng
Schlagworte:	Atomic and molecular physics Base Sequence Biological and medical sciences Chemical Phenomena Chemistry, Physical Coding Cross-disciplinary physics: materials science rheology Deoxyribonucleic acid DNA DNA - chemistry Exact sciences and technology Flow Charts Fundamental and applied biological sciences. Psychology Gels General aspects Genetic translation Ligation Literary Devices Macromolecules and polymer molecules Materials Materials science Molecular biophysics Molecules Nanoscale materials and structures: fabrication and characterization Nanostructures Nanotechnology Nucleic Acid Conformation Nucleotides Organic Chemistry Other topics in nanoscale materials and structures Oxygen Physics Polymers Polymers - chemistry Product labeling Protein Biosynthesis Ribosomes Ribosomes - metabolism RNA, Transfer - metabolism Semitic Languages Studies of special atoms, molecules and their ions clusters Topology Translation Translation (Genetics)
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Beschreibung
Zusammenfassung:	We developed a DNA nanomechanical device that enables the positional synthesis of products whose sequences are determined by the state of the device. This machine emulates the translational capabilities of the ribosome. The device has been prototyped to make specific DNA sequences. The state of the device is established by the addition of DNA set strands. There is no transcriptional relationship between the set strands and the product strands. The device has potential applications that include designer polymer synthesis, encryption of information, and use as a variable-input device for DNA-based computation.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1104299