Age and facial nerve axotomy-induced T cell trafficking: Relation to microglial and motor neuron status

Research highlights ► More CD3+ T cell in the injured FMN in 52-week-old mice than 8-week-old mice. ► Differences in CD11b+ clusters between 8- and 52-week-old mice in the injured FMN. ► Cumulative neuronal loss did not differ between 8- and 52-week-old mice. ► There was a small reduction in the siz...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2011-01, Vol.25 (1), p.77-82
Hauptverfasser:	Dauer, Daniel J, Huang, Zhi, Ha, Grace K, Kim, Jeremy, Khosrowzadeh, David, Petitto, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging - physiology Allergy and Immunology Animals Axotomy CD11b Antigen - metabolism CD3 Complex - metabolism Cell Count Cell Death - physiology Cell Size Facial Nerve - pathology Facial Nerve - physiology Facial nerve axotomy Immunohistochemistry Male Mice Mice, Inbred C57BL Microglia - immunology Motor neuron loss Motor Neurons - physiology Neurons - pathology Perineuronal microglial phagocytic clusters Psychiatry Resection T cells T-Lymphocytes - immunology Trafficking
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Zusammenfassung:	Research highlights ► More CD3+ T cell in the injured FMN in 52-week-old mice than 8-week-old mice. ► Differences in CD11b+ clusters between 8- and 52-week-old mice in the injured FMN. ► Cumulative neuronal loss did not differ between 8- and 52-week-old mice. ► There was a small reduction in the size of the surviving motor neurons in older mice.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2010.08.005