Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis
Purpose There have been many studies concerning the associations of angiotensin-converting enzyme (ACE) I/D , angiotensinogen (AGT) M235T polymorphisms with pregnancy induced hypertension (PIH) among Chinese populations. However, the results were inconsistent, prompting the necessity of meta-analysi...
Gespeichert in:
Veröffentlicht in: | Journal of assisted reproduction and genetics 2012-09, Vol.29 (9), p.921-932 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Purpose
There have been many studies concerning the associations of angiotensin-converting enzyme (ACE)
I/D
, angiotensinogen (AGT)
M235T
polymorphisms with pregnancy induced hypertension (PIH) among Chinese populations. However, the results were inconsistent, prompting the necessity of meta-analysis.
Methods
Studies published in English and Chinese were mainly searched in EMbase, PubMed and CBM up to January 2012.
Results
Twenty-three studies with 3,551 subjects for
ACE I/D
and seven studies with 1,296 subjects for
AGT M235T
were included. Significant associations were found between
ACE I/D
and PIH under dominant, recessive and allelic models. A separate analysis confined to preeclampsia suggested that
ACE I/D
was associated with preeclampsia under recessive model and allelic model, but not dominant model. Stratified analyses were conducted as meta-regression analysis indicated that the sample size of case group was a significant source of heterogeneity, which suggested no significant association between
ACE I/D
and PIH in the subgroup of more than 100 cases. Associations were found between
AGT M235T
and PIH under dominant genetic model (OR = 1.59; 95 %CI: 1.04–2.42), recessive genetic model (OR = 1.60; 95 %CI: 1.07–2.40), and allelic model (OR = 1.40; 95 %CI: 1.17–1.68). No publication bias was found in either meta-analysis.
Conclusions
The present meta-analysis suggested significant associations between
ACE I/D, AGT M235T
and PIH in Chinese populations. However, no significant association was found between
ACE I/D
and PIH in the subgroup of more than 100 cases. Studies with larger sample sizes are necessary to investigate the associations between gene polymorphisms and PIH in Chinese populations. |
---|---|
ISSN: | 1058-0468 1573-7330 |
DOI: | 10.1007/s10815-012-9800-4 |